The impact of COVID-19 pandemic on the world's major economies: based on a multi-country and multi-sector CGE model.

Objective: To quantitatively assess the impact of COVID-19 pandemic on public health, as well as its economic and social consequences in major economies, which is an international public health concern. The objective is to provide a scientific basis for policy interventions. Subject and methods: This study utilizes a multi-country, multi-sector CGE-COVID-19 model to analyze the repercussions of the pandemic in 2022. The re-search focuses on quantifying the effects of COVID-19 on the macroeconomy and various industry sectors within six economies: the United States, China, the EU, the United Kingdom, Japan, and South Korea. Results: The COVID-19 pandemic shock had the most significant impact on China and the EU, followed by notable effects observed in the United States and the United Kingdom. In contrast, South Korea and Japan experienced relatively minimal effects. The reduction in output caused by the pandemic has affected major economies in multiple sectors, including real industries such as forestry and fisheries, and the services such as hotels and restaurants. Conclusion: The overall negative macroeconomic impact of the epidemic on major economies has been significant. Strategic interventions encompassing initiatives like augmenting capital supply, diminishing corporate taxes and fees, offering individual subsidies, and nurturing international cooperation held the potential to mitigate the detrimental economic consequences and enhance the global-economic amid the pan-demic. Consequently, this study contributes to the advancement of global anti-epidemic policies targeting economic recovery. Moreover, using the CGE-COVID-19 model has enriched the exploration of general equilibrium models in PHEIC events.

hsa_circ_0023305 Enhances Laryngeal Squamous Cell Carcinoma Progression and Modulates TRPM7 via miR-218-5p Sponging.

Recently, circular RNAs have been shown to function as critical regulators of many human cancers. However, the circRNA mechanism in laryngeal squamous cell carcinoma (LSCC) remains elusive. Recent investigations using bioinformatics analysis revealed high expression of hsa_circ_0023305 in LSCC tissues compared to normal tissues. Furthermore, we discovered that hsa_circ_0023305 expression level was positively correlated to tumor/node/metastasis (TNM) stage as well as lymph node metastasis in LSCC. Moreover, higher hsa_circ_0023305 levels were correlated to poorer LSCC patient outcomes. Knockdown of hsa_circ_0023305 significantly inhibited LSCC cell proliferation, invasion, and migration abilities. Our team validated that hsa_circ_0023305 functioned as a miR-218-5p sponge from a mechanistic perspective, targeting the melastatin-related transient receptor potential 7 (TRPM7) in LSCC cells. TRPM7 regulates a nonselective cation channel and promotes cancer proliferation and metastasis. Our data demonstrated that miR-218-5p was downregulated in LSCC and that miR-218-5p upregulation repressed LSCC proliferation and invasion both in vivo and in vitro. Additionally, we found that hsa_circ_0023305-mediated upregulation of TRPM7 inhibited miR-218-5p and contributed to LSCC migration, proliferation, and invasion. In summary, these data propose a new mechanism by which the hsa_circ_0023305/miR-218-5p/TRPM7 network enhances LSCC progression.

Scanning high-power continuous wave laser-generated bulk acoustic waves.

The ultrasonic bulk waves generated by a high-power continuous laser scanning along the surface of aluminum material were theoretically investigated. Although the temperature rise generated by this scanning laser irradiation was small, it provided a large temperature gradient, which was able to generate measurable ultrasonic waves. Detailed discussions were given to the influence of scanning speed on the generation propagation direction and the amplitude of the wavefront. The longitudinal and transverse waves would be generated in the material only when the scanning speeds reached a certain range. What's more, the amplitude of the wavefronts were significantly enhanced if the wavefront angle controlled by the scanning speed matched with the propagation direction of the ultrasound. In summary, it expounded a method to obtain the ultrasonic signal of direction, controlled from the perspective of numerical simulation, as long as the scanning speed met the requirements.

Orbital-type trapping of elastic Lamb waves.

The interaction of laser-generated Lamb waves propagating in a plate with a sharp-angle conical hole was studied experimentally and numerically. Part of the energy of the incident wave is trapped within the conic area in two ways: the antisymmetric Lamb wave orbiting the center of the hole and the wave localized at the acute edge. Parameters and conditions for optimal conversion of the incident wave into the trapped modes were studied in this work. Experiments were performed using the laser stroboscopic shearography technique, which delivers the time evolution of the acoustic field in the whole area of interest. The effect of trapping can be used for efficient damping, similar to the one-dimensional acoustical black hole effect.